Mepivacaine hydrochloride

Research use only, not for human use.

Mepivacaine is a tertiary amine used as a local anesthetic.

Mepivacaine is a tertiary amine used as a local anesthetic.(In Vitro):Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action.Mepivacaine hydrochloride has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine).Mepivacaine hydrochloride displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels.

Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action.Mepivacaine hydrochloride has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine).Mepivacaine hydrochloride displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels.

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Membrane Transporter/Ion Channel

Sodium Channel

Sodium Channel

Neurological Disease

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1722-62-9

282.81

C15H22N2O·HCl

>98% (HPLC)

Ethanol: 8 mg/mL (28.28 mM); Water: 57 mg/mL (201.54 mM); DMSO: 3 mg/mL (10.6 mM)

Cl.CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C

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(-20℃)

With Ice Pack

≥ 2 years